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Transplant patient and now doctor, Frankie starts her first day in Renal rotation; best friend Lou battles surgery's boys' club; and flatmate Tabb starts as an intern.

Frankie takes on the system to save a patient, and lands in trouble. Lou finds out it’s not always wise to have an affair with a boss; and Tabb questions his ability as a doctor.

When a heart transplant patient dies, Frankie fears the surgeons will close ranks to cover up a medical error. Lou realises she and best friend Frankie may be on different sides.

When a patient wants to turn off the device keeping her alive, Steele tries to dissuade her. Lou feels betrayed when Frankie takes on a Root Cause Analysis into a patient’s death, threatening her job.

When Berger learns Frankie has a fever in the middle of a hospital outbreak, he forces her into a bed for treatment, putting her secret at risk of exposure.

Tanya Kalchuri is forced to tell Frankie she read her medical files - a breach of professional ethics; while Berger works with Eli Nadar to save a patient from deportation.

On the eve of an investigation into a patient's death, Frankie realises that all doctors are fallible when faced with the reality of a health system that isn't always able to cater for all.

Chad Berger's days as a doctor are coming to an end, but he is determined to see through a complex set of paired kidney exchange transplants. Will he be able to do so, or will his own condition get to him?